73,677,287
Total sRNA Sequences
20,758,257
Unique sRNA Sequences
21,757
miRBase-Aligned miRNAs
245
Traditional Botanicals Sequenced
Genomic Scale & Profiling
- A modified herbal extraction protocol performed RNA sequencing across 245 traditional botanical medicines, generating 73.6M total sRNA sequences.
- Identified 20.7M unique sRNAs and cataloged 21,757 miRNAs whose profiles match known plant miRNAs in miRBase.
Cross-Kingdom Regulation
- Computational modeling and experimental validation proved Atlas sRNAs can regulate human target genes across the entire human genome.
- Establishes plant-derived cross-kingdom sRNAs as a major bioactive class operating alongside traditional small-molecule secondary metabolites.
The Decoctosome Delivery Engine
0.5% – 2.5%
Lipoprotein nanoparticles constituting the bulk of traditional herbal decoctions
Enzyme Shield
Decoctosomes protect herbal sRNAs from degradation during digestion
Intact Uptake
Enables cross-kingdom uptake into human blood cells & peripheral tissues
COVID-19 Clinical Validation
- Cohort analysis of COVID-19 patients treated with Toujie Quwen (TQ) granules confirmed thousands of herbal sRNAs entering human blood cells and downregulating disease-associated differentially expressed genes (DEGs).
- Screening 245 TCMs against 337 upregulated DEGs in mild COVID-19 identified 33 top effective botanicals with >50% target-gene overlap.
The Quantitative Bencao Index
A five-vector quantitative framework measuring standardized natural-product efficacy.
SMSmall-molecule active compounds
PProtein peptides
NNucleic acids (incl. cross-kingdom sRNAs)
LMNon-nucleic, non-proteinogenic large molecules
ETrace elements (Mendeleev periodic table)
8-Factor Analysis · Mitragyna speciosa
CSA abuse-liability scheduling brief for kratom alkaloids — factors, evidence matrix, and recommendation.